In November 2016, writer and director Fede รlvarez announced that a sequel was in the works.Producer Sam Raimi commented on the sequel and was quoted saying, "It s only the greatest idea for a sequel I ve ever heard. I m not kidding."In November 2018, รlvarez announced the script for the sequel was completed.

In January 2020, the title was announced as Don t Breathe 2. The film was to begin principal photography in the April 2020, with a script co-written by Rodo Sayagues and รlvarez, but was delayed due to the COVID-19 pandemic.Eventually, Sayagues served as director, while the latter served as a producer.On October 8, 2020, Lang revealed filming had completed.The film was released on August 13, 2021.

In November 2016, writer Fede รlvarez announced that a sequel to Don t Breathe was in the works, and that he was set to return as director.[9] Producer Sam Raimi called it "only the greatest idea for a sequel I ve ever heard. I m not kidding."[10] In November 2018, รlvarez discussed sequels to both his Don t Breathe and Evil Dead, saying, "They re just ideas right now. Nothing to announce officially. We do have a script for Don t Breathe 2. That s the only difference. We don t have a script for Evil Dead 2. But we do have a script for Don t Breathe 2 that we wrote." He also said, "When I tweeted that I was interested in seeing what people prefer. We were having some internal debates about what people would be interested in most. Unfortunately, Evil Dead 2 won. Which, I guess I would have preferred Don t Breathe 2 to win because it s one of my own creations. Obviously Evil Dead has the bigger following."


In January 2020, รlvarez was replaced as director by Rodo Sayagues, the co-writer of both Don t Breathe films, making his directorial debut.[4][14] In a March 2021 interview, Stephen Lang stated that in preparation for reprising the role of Norman Nordstrom, he worked with The Northeastern Association for the Blind in Albany, New York to accurately depict the mannerisms of someone afflicted with being blind.

Principal photography began on August 7, 2020,in Belgrade, Serbia,with Pedro Luque serving as cinematographer, returning from the previous film.Production was previously set to begin in April 2020, but was delayed due to the COVID-19 pandemic.In July 2020, prior to filming, Stephen Lang quarantined himself for ten days after arriving in Serbia.Lang revealed that filming wrapped on October 8, 2020.By March 2021, post-production on the film was said to be finished, according to รlvarez, who "watched it not too long ago," calling it "fantastic," and later stating he thinks it s better than the first film. In May 2021, Roque Baรฑos was revealed to have composed the score for Don t Breathe 2, having returned from the first film.During post-production, Jan Kovac served as lead editor.